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Optoelectronics for Neural Recording and Stimulation

“Optoelectronics for
Neural Recording and Stimulation”
Polina Anikeeva, PhD
CSNE Member & Assistant Professor
Departments of Materials Science and Engineering
Massachusetts Institute of Technology, Cambridge, MA
Recently the invention of optogenetics have allowed for high-speed control of genetically defined
neural circuit elements in freely moving mammals. However, with the ability to control came the
demand to monitor neural activity during optogenetic experiments. To address the need for
simultaneous optical stimulation and electrophysiological recording we have recently demonstrated a
low-cost, miniature device “Optetrode”. The Optetrode’s small dimensions and modest weight (~2g)
have allowed us to investigate the effects of optical excitation and inhibition of several genetically
distinct cell populations in the prefrontal cortex of freely moving mice during the open field test. We
have also demonstrated the utility of the Optetrode in electrophysiological recording and optical
stimulation of projections from basolateral amygdala to the prefrontal cortex. Recently my lab has
been focusing on extending the Optetrode concept to higher-resolution electrophysiological
recordings and the development of flexible optoelectronic neural recording and stimulation devices
that allow for greater tissue compatibility.
Wednesday, June 6, 2012
3:30 PM – 4:30 PM
SDSU will connect via videoconference from SDSU,
room E203e
Space is limited, please arrive early; contact Theresa M. Garcia, for questions

videoconference seminar anikeeva 6’6’12

Published in Research STEM Activities